Dejal Systems, LLC produces Simon, a web site monitoring tool for Mac OS X. It checks sites for changes or failures, and notifies you via e-mail, sound, speech, or other means. You can use it to track updated sites, and to alert you when an important site goes down or recovers.
Version 2.5.7 makes the following changes:
Simon is available in a number of configurations, ranging in price from $29.95 ("Basic" license allowing up to 7 tests) to $195 ("Enterprise" license allowing unlimited tests). The online store offers full details.
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Also, if you have an older Mac, be sure to check out the "Classic" applications page for more options.
Finally, take a look at ALEMIA if you think you know that name of an application, but aren't quite sure.
These are applications that are newer and of potential interest, but which I haven't yet selected for permanent inclusion. Have a look, and let me know if you think they deserve to be part of the permanent collection!