SpamSweep is an advanced Bayesian spam filter with a simple, easy to understand interface. SpamSweep seamlessly combines many filtering technologies, including domain and relay blacklists, sender whitelisting, and a bayesian filter to automatically delete spam messages before they're downloaded by your email client.
SpamSweep can notify you when you have new good mail by playing a sound, displaying the new messages in a floating window, or launching your email client. Features include:
Version 1.6.2 adds/changes the following:
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Also, if you have an older Mac, be sure to check out the "Classic" applications page for more options.
Finally, take a look at ALEMIA if you think you know that name of an application, but aren't quite sure.
Graham Orndorff has written a superb collection of articles on setting up email servers and secure email clients on Mac OS X.
Adam Engst has put together a comprehensive overview of email attachment formats that is invaluable for anyone who wants or needs to understand the complexities behind them.
These are applications that are newer and of potential interest, but which I haven't yet selected for permanent inclusion. Have a look, and let me know if you think they deserve to be part of the permanent collection!