Hendrickson Software Components produces Purify, a desktop-based, automated email filtering software system that supports almost every email client. Purify was designed from the ground up with ease of use and simplicity in mind. It may be used standalone, and it can also easily support a workgroup from a central computer. The Macintosh version is a completely AppleScript-able Universal Binary, and has been tested on Mac OS X 10.5 (Leopard). The Macintosh version also comes with a complete set of AppleScripts that can be tailored by the user to exactly fit their needs. Features include:
Purify is designed as a replacement for Hendrickson's Sp@mX and Em@ilCRX products, both of which are now discontinued.
Version 2.2.1 adds/changes the following:
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Also, if you have an older Mac, be sure to check out the "Classic" applications page for more options.
Finally, take a look at ALEMIA if you think you know that name of an application, but aren't quite sure.
Graham Orndorff has written a superb collection of articles on setting up email servers and secure email clients on Mac OS X.
Adam Engst has put together a comprehensive overview of email attachment formats that is invaluable for anyone who wants or needs to understand the complexities behind them.
These are applications that are newer and of potential interest, but which I haven't yet selected for permanent inclusion. Have a look, and let me know if you think they deserve to be part of the permanent collection!