POPmonitor lets you delete unwanted e-mail from your mailbox without downloading it to your computer first, and allows you to trash messages with large attachments without the need to download them to your computer first. Just login, select the unwanted messages and click 'Delete.'
Version 2.1.3 makes the following changes:
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Also, if you have an older Mac, be sure to check out the "Classic" applications page for more options.
Finally, take a look at ALEMIA if you think you know that name of an application, but aren't quite sure.
Graham Orndorff has written a superb collection of articles on setting up email servers and secure email clients on Mac OS X.
Adam Engst has put together a comprehensive overview of email attachment formats that is invaluable for anyone who wants or needs to understand the complexities behind them.
These are applications that are newer and of potential interest, but which I haven't yet selected for permanent inclusion. Have a look, and let me know if you think they deserve to be part of the permanent collection!